By Friðjónsson, Jón
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During this bankruptcy ve shall talk about the calculation of power strength linked vith molecular conforaations. Raving got cartesian atoaic coordinates defining conforaations. and lists of intraao- cular interactions, as defined in bankruptcy three, ve are able to calculate a volume which within the chemical literature is named the whole aolecular power power or the conforaational, steric, pressure or intraaolecular strength.
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Dopamine also has vasoconstrictor activity. At first this was thought to be due to stimulation of a-adrenoceptors since responses could be blocked by phenoxybenzamine. But phenoxybenzamine is not a selective blocking agent, and later experiments in isolated tissues suggested that serotonin (5-HT) receptor stimulation might also be in- volved. Experiments in anaesthetized dogs revealed further differences between the actions of dopamine and those of other catecholamines. In barbiturate-anaesthetized animals, in which sympathetic tone is relatively low, dopamine increases systolic blood pressure dose-dependently, but at low doses, diastolic pressure is reduced (Fig.
Subsequent administration ofdopamine produced the cardiovascular and renal responses shown. The amine was infusedfor a further J8 h with no deterioration in cardiovascular status  2 D 0 [20 Dextran Urine volume ml/min ~ I 12 pm I 1 am [,0 2 but is selectively attenuated by neuroleptic compounds, which are known to block dopamine receptors in the central nervous system. The extensive work of Goldberg and his colleagues has led to the concept that the dilator effect of dopamine on renal and splanchnic vessels is due to stimulation of receptors which are specific for the amine .
Also the rank order of uptake of the two substances in different organs should be the same. When radioactive dopamine is injected intravenously into the guinea pig, however, the highest amounts accumulate in the kidneys,followed in decreasing order, by the lungs, liver, spleen, heart and plasma. By contrast, labelled noradrenaline accumulates (in decreasing order) in the spleen, lungs, heart, adrenals, kidneys, liver, small intestine and plasma. 04 100-700 Noradrenaline and adrenaline - The Role of Dopamine in the Periphery 29 Table 2.
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