By Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science

Meantime file of the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies: evaluation of correct technology, convened to supply suggestion to the U.S. division of safeguard concerning prion disorder. specializes in the examine had to enhance diagnostics for prion illnesses and discusses prion examine infrastructure concerns. Softcover.

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Caughey B. 2002. The PrP conversion process. Presentation to the IOM Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Meeting II. C. Chernoff YO, Lindquist SL, Ono B, Inge-Vechtomov SG, Liebman SW. 1995. Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]. Science 268(5212):880-884. Chesebro B. 1998. BSE and prions: uncertainties about the agent. Science 279(5347):4243. Chesebro B. 1999. Prion protein and the transmissible spongiform encephalopathy diseases.

Research on TSEs in Blood The committee also concluded that more research is needed to determine the risks of acquiring vCJD and sporadic Creutzfeldt-Jakob disease (sCJD) from blood products. This risk was judged to be small but unknown. Since accurate antemortem tests for the detection of prions in humans are not available, conservative health policies have been established. , 2002), caution dictates that individuals who have been exposed to BSE-tainted beef products be prevented from donating blood or organs.

There are about 20 30 ADVANCING PRION SCIENCE phenotypically distinct, mouse-passaged strains of scrapie alone (Haywood, 1997). Despite these advances, much about prion strains remains a mystery. It is unclear why strain variants exist in the first place. Researchers must be able to differentiate one strain from another, determine the scope of strain diversity, determine the special characteristics of a strain’s conformation that make the strain unique, determine a host’s susceptibility to various strains, and determine how incubation periods and patterns of disease expression vary by strain and host.

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